Monday 10 December 2012

Bilharzia


Description

  • Bilharzia is a parasitic disease caused by worms.
  • Bilharzia causes chronic ill health.
  • It is the second most prevalent tropical disease.
  • It is the eggs, and not the worm, that damage the intestines, the bladder and other organs.
  • There is a link between urinary bilharzia and a form of bladder cancer in some areas.
  • Because the disease is chronic, it adversely affects the socio-economic development of tropical and subtropical regions.
  • If bilharzia is left untreated, serious complications may occur.

Five species of the flatworm or blood flukes, also known as schistosomes, cause the main forms of human bilharzia or schistosomiasis. They are:

  • Schistosoma mansoni – intestinal bilharzia which is prevalent in 53 countries and areas of Africa, the Caribbean, the Eastern Mediterranean and South America
  • Schistosoma japonicum/Schistosoma mekongi – intestinal bilharzia
  • Schistosoma intercalatum – urinary bilharzia
  • Schistosoma haematobium – urinary bilharzia, which affects 54 countries in Africa and the Eastern Mediterranean

Only Schistosoma mansoni and Schistosoma haematobium are found in Southern Africa.

A person gets bilharzia when his/her skin comes into contact with contaminated fresh water. The parasites enter the skin, then migrate through the body to the blood vessels of the lungs and liver. From there they may advance to the veins around the bowel or bladder. The worms will lay eggs which can either be passed in the urine or faeces, or remain in the tissues in the human host. Eggs that remain in the host are usually found in the liver (S. mansoni) or the bladder (S. haematobium).

Infected people can infect fresh water if they urinate or defecate in it.

This will start a new cycle of infection when contaminated water is used in ordinary daily activities such as washing, bathing and swimming or professional activities.

Cause

About 600 million people are at risk of becoming infected with this parasitic disease, the underlying causes of which include the following:

  • Extreme poverty
  • Unawareness of risks
  • Inadequacy or lack of public health facilities
  • Unsanitary living conditions
  • Migratory people and refugees from countries where the disease is endemic
  • Rapid urbanisation
  • Increase in tourism to places that are off the beaten track

Symptoms

Within days of becoming infected with the bilharzia parasite, a rash or itchy skin (swimmer’s itch) may appear. This normally settles spontaneously. Within another month or two a person who has been infected may experience fatigue, fever, chills, cough, muscle aches, abdominal pain, diarrhoea, dysentery and blood in the urine. This phase coincides with the maturation of the worms in the body, and is called Katayama fever.

In chronic bilhazia, it is the body’s reaction to the worm’s eggs, laid in the liver, intestine or bladder that causes the symptoms associated with bilharzia. Eggs are rarely found in the brain.

Blood in the urine is a clear indication of urinary bilharzia, and is the commonest symptom of this type of bilharzia. In the case of intestinal bilharzia, symptoms may initially be so atypical that diagnosis is difficult. If left untreated, these symptoms can lead to serious complications of the liver and spleen.

Blood in the urine is a clear indication of urinary bilharzia. In the case of intestinal bilharzia, symptoms may initially be so atypical that diagnosis is difficult. If left untreated, these symptoms can lead to serious complications of the liver and spleen.

Prevalence

The disease commonly affects the following people:
  • Adult workers in agriculture and the freshwater fishing sector. Although these workers usually have only light infections and do not suffer from any symptoms, bilharzia infection has seriously affected the productivity of such workers in north-east Brazil, Egypt and Sudan.
  • Urinary bilharzia affects 66 million children in more than 54 countries.
  • In many areas children between 10 and 14 years of age are infected. The disease substantially affects children’s growth and school performance.

Course

Because of a lack of information or not enough attention to hygiene, people who are already infected with the parasite contaminate their fresh water supply by urinating and defecating in it. The eggs of the schistosomes in the excrement hatch when they come into contact with water and release a parasite, called the miracidium. To survive, this parasite must find a fresh water snail. Once it has found its snail host, the miracidium divides and produces thousands of new parasites or cerceriae, which the snail in turn excretes in the surrounding water. Here it can survive for 48 hours. Any person coming into contact with this water can be infected by the cercariae.

When the new parasites have entered a person’s skin (it can happen in a few seconds), they migrate to the blood vessels of the lungs. From there they migrate to the blood vessels of the liver and intestines (Schistosoma mansoni) and bladder (Schistosoma haematobium). Bilharzia continues its life cycle in the blood vessels of the intestines (in the case of intestinal bilharzia) or the bladder (in the case of urinary bilharzia) of the victim.

In 30 to 45 days a cerceriae is transformed into a long worm. The female worms lay between 200 and 2 000 eggs per day over an average of five years. It is the eggs and not the worm that cause the damage to the bladder, intestines and other vital organs, such as the liver. The body's reaction to the eggs in the liver can cause fibrosis in the liver, which in turn causes enlargement of the spleen, and dilation of some of the blood vessels, especially in the base of the oesophagus.

Risk factors

You may get infected with bilharzia if:

  • You live in or travel to areas where bilharzia occurs.
  • Your skin comes into contact with contaminated fresh water from canals, rivers, streams or lakes.

When to see a doctor

  • If you have travelled to an area where bilharzia is found.
  • If your skin has come into contact with fresh water in such an area.
  • If you have blood in your urine.

 

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